People with SLE have episodes in which the condition gets worse (exacerbations) and other times when it gets better (remissions). Anxiety and depression are also common in SLE. The inflammation characteristic of SLE can also damage the nervous system, and may result in abnormal sensation and weakness in the limbs (peripheral neuropathy) seizures stroke and difficulty processing, learning, and remembering information (cognitive impairment). Heart disease caused by fatty buildup in the blood vessels ( atherosclerosis ), which is very common in the general population, is even more common in people with SLE. Heart problems may also occur in SLE, including inflammation of the sac-like membrane around the heart (pericarditis) and abnormalities of the heart valves, which control blood flow in the heart.
Affected individuals may also have hair loss (alopecia) and open sores (ulcerations) in the moist lining (mucosae) of the mouth, nose, or, less commonly, the genitals.Ībout a third of people with SLE develop kidney disease (nephritis). Petechiae are caused by a shortage of cells involved in clotting (platelets), which leads to bleeding under the skin.
#Dead cells malaise skin
Other skin problems that may occur in SLE include calcium deposits under the skin (calcinosis), damaged blood vessels (vasculitis) in the skin, and tiny red spots called petechiae. The rash, which generally does not hurt or itch, often appears or becomes more pronounced when exposed to sunlight. A characteristic feature is a flat red rash across the cheeks and bridge of the nose, called a "butterfly rash" because of its shape.
Most affected individuals also have joint pain, typically affecting the same joints on both sides of the body, and muscle pain and weakness. SLE may first appear as extreme tiredness (fatigue), a vague feeling of discomfort or illness (malaise), fever, loss of appetite, and weight loss. SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs. The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and blood-forming (hematopoietic) system. Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body.
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